Ryan and his crew become the subjects in a deadly experiment when they're taken captive inside a redoubt at the South Pole. A team of scientists is convinced the earth must be purified of mutants, and now they have the perfect lab rats to test their powerful bioweapon. Filled with toxic chemicals and faced with Antarctica's harsh and unstable conditions, the companions must fight the odds and take down the whitecoats before millions are killed. But in this uncompromising landscape, defeating the enemy may be just another step toward a different kind of death....